Filling your system drive up with sample data is a bad idea not just from a performance perspective but from a data management one.
The default install for developers is C but this is not because its the best directory to use.
Storing large amounts of data on C drive makes backups more complex and slow, just like storing data on your desktop makes loading times for windows slow.
There literally is no reason to store samples or document data on the system drive in 2022.
I have my C drive for windows and programs and thats it.
Samples are stored on multiple SSD's pooled together into one drive volume labelled X:
I use Stablebit drive pool
This means...Kontakt, Native access, Spitfire player, Orchestral Tools sine juts focus on one drive letter X:
Windows drive becomes corrupt? I don't care... I can format and reinstall windows from an image file and point eveyting to X: in seconds.
I can add SSD's to the pool in seconds and all the sample players are unaffected and X: just gets expanded.
Here is an example Drivepool X:
As said samples on Mine are stored by Vendor
Drivepool X:
Spitfire
Native Instruments
Audio Imperia
etc...
My pool currently is a mixture of 2 x 2TB SSD and 1 X 4 TB for a drive pool of 8TB
Now all you have to do in the future in mange one drive letter X for everything. You just ignore the other drives completely. You can even hide them in windows so you dont see them.
So my a new spitfire library you down load it to Drivepool X: Spitfire
Point Native Access to Drivepool X: Native Access
Point OT Sine to Drivepool X: Sine
etc....
Makes things so easy to manage as all your sample are now on one single volume called Drivepool X:
Backup are super easy as you dont need to remember directories any more and makes backing up super simple.
I backup my Drivepool to a server also running Drivepool
Start running out of space on the pool? No problem just install new SSD in PC add the drive to the existing drivepool and voila the drivepool expands in seconds.
Want to remove a drive from the pool? No problem just remove it as long as there is enough free space in the pool to migrate the data.
PC dies one day? No problem you can access the data from any computer wether it has drivepool installed or not.
I'm down to 705GB free on my Pool and looking to add another 4TB SSD come amazon prime sales time. I dont have to do anything with my samples or data. I just add the 4TB SSD to the pool and the pool expands without me having to faff with moving files etc.
Hope this helps.